Mei 2016
30
Bijlage 2: Risicomedicatie bij mitochondriële aandoeningen
2
Antibiotica
1
(chlooramfenicol
2
,
tetracyclines
3
)
Neuroleptica
1
(haloperidol
6,7
, quetiapine
7
,
chloorpromazine
6,7
,
risperidon
6,7,8
)
Anti-epileptica
1
(valproïnezuur
3,11,12.,13,14
)
Narcosemiddelen
1
Corticosteroïden
1
Chemotherapeutica
1
Lipidenverlagende middelen
1
Anti-arrhytmica
1
(amiodaron
3
)
Antiretrovirale middelen
1
Antidiabetica
1
(biguanides
4,5
,
thiazolidinedionen
9,10
Anti- depressiva
15
(SSRI
15
)
Analgetica
1
(acetylsalicylzuur
3,11
,
ibuprofen
11
)
Referenties
1)
Finsterer J, Segall L. Drugs interfering with mitochondrial disorders. Drug Chem Toxicol
2010; 33: 138-51
2)
Mottin S, Laporte P, Cespuglio R. Inhibition of NADH oxidation by chloramphenicol in the
freely moving rat measured by picosecond time-resolved emission spectroscopy. J
Neurochem 2003; 84: 633-42.
3)
Fromenty B, Pessayre D. Inhibition of mitochondrial beta-oxidation as a mechanism of
hepatotoxicity. Pharmacol Ther 1995; 67: 101-54.
4)
Guigas B, Detaille D, Chauvin C et al. Metformin inhibits mitochondrial permeability
transition and cell death: a pharmacological in vitro study. Biochem J 2004; 382: 877-84.
5)
Carvalho C, Correia S, Santos MS et al. Metformin promotes isolated rat liver mitochondria
impairment. Mol Cell Biochem 2008; 308: 75-83.
6)
Casademont J, Garrabou G, Miró O et al. Neuroleptic treatment effect on mitochondrial
electron transport chain: peripheral blood mononuclear cells analysis in psychotic patients.
J Clin Psychipharmacol 2007; 27: 284-8.
7)
Modica-Napolitano JS, Lagace CJ, Brennan WA, Aprille JR. Differential effects of typical and
atypical neuroleptics on mitochondrial function in vitro. Arch Pharm Res 2003; 26: 951-9.
8)
Ahn MS, Sims KB, Frazier JA. Risperidone-induced psychosis and depression in a child with
a mitochondrial disorder. J Child Adolesc Psychopharmacol 2005; 15: 520-5.
2
Vries, M.C. de, Smeitink, J. & Coo, I.F.M. de. (2014).
Risico’s van medicatie bij mitochondriёle aandoeningen
